Voriconazole QVORIC

Method(s) Chromatography/Mass Spectrometry
Specimen Required
Collect

One 5 mL plain red top tube (no gel). Also acceptable: plasma in dark green (sodium heparin) top tube.

Transport

2 mL serum refrigerated (Min: 1 mL).

Stability

Ambient: 5 days

Refrigerated: 5 days

Frozen: 30 days

Unacceptable Conditions
  • Serum separator tubes (SST)
  • Other body fluids
  • Other specimen types
Schedule Mon-Sat 8:00 a.m.; Report available: 1-2 days
Billing Code 9011753
CPTCode 80285
Notes Performing Laboratory Quest Diagnostics Nichols Institute-Valencia, CA
Preferred Specimen Collection Device(s)
Reference Interval

Steady state trough levels are achieved within 1 day when an IV loading dose is used and after approximately 5 days of oral or IV therapy without a loading dose.

Therapeutic range
Prophylaxis: trough greater than 0.5 mcg/mL
Therapeutic range for treatment: trough 2.0-5.5 mcg/mL

Serum trough levels less than or equal to 1 mcg/mL are reported to be associated with lack of therapeutic response and serum trough levels greater than 5.5 mcg/mL have been reported to be associated with reversible neurological adverse events and hepatotoxicity.

Co-administration of drugs that metabolically induce or inhibit CYP2C19, or other conditions that affect CYP2C19 may alter voriconazole metabolism.

No Appointment Necessary
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