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Voriconazole QVORIC

Specimen Required
Method(s)	Chromatography/Mass Spectrometry
Collect	One 5 mL plain red top tube (no gel). Also acceptable: plasma in dark green (sodium heparin) top tube.
Transport	2 mL serum refrigerated (Min: 1 mL).
Stability	Ambient: 5 days Refrigerated: 5 days Frozen: 30 days
Unacceptable Conditions	Serum separator tubes (SST) Other body fluids Other specimen types

Schedule	Mon-Sat 8:00 a.m.; Report available: 1-2 days
Billing Code	9011753
CPTCode	80285
Notes	Performing Laboratory Quest Diagnostics Nichols Institute-Valencia, CA
Preferred Specimen Collection Device(s)
Plain Red Cap Tube with Clot Activator Dark Green Cap Tube with Lithium Heparin
Reference Interval
Steady state trough levels are achieved within 1 day when an IV loading dose is used and after approximately 5 days of oral or IV therapy without a loading dose. Therapeutic range Prophylaxis: trough greater than 0.5 mcg/mL Therapeutic range for treatment: trough 2.0-5.5 mcg/mL Serum trough levels less than or equal to 1 mcg/mL are reported to be associated with lack of therapeutic response and serum trough levels greater than 5.5 mcg/mL have been reported to be associated with reversible neurological adverse events and hepatotoxicity. Co-administration of drugs that metabolically induce or inhibit CYP2C19, or other conditions that affect CYP2C19 may alter voriconazole metabolism.