Metanephrines, Urine METU

Method(s) Quantitative High Performance Liquid Chromatography/ Tandem Mass Spectrometry
Specimen Required
Collect 24-hour urine or random urine. Refrigerate during collection.
Transport

4 mL aliquot from well mixed 24 hour or random collection at 2-8°C. (Min: 2.5 mL)

Remarks

Specimen Preparation:

Thoroughly mix entire collection (24-hour or Random) in one container. Transfer a 4 mL aliquot tube (Min: 2.5 mL). A pH lower than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form.

Specimen preservation can be extended to 1 month refrigerated by performing one of the following:
Option 1: Transfer a 4 mL aliquot tube (Min: 2.5 mL) Adjust pH to 2.0-4.0 with 6M HCI.
Option 2: Transfer a 4 mL aliquot tube containing 20 mg sulfamic acid. (Min: 2.5 mL)

Stability

Ambient: Unacceptable; Refrigerated: 2 weeks (unpreserved), 1 month (preserved); Frozen: 1 month

Schedule Daily
Billing Code 5011190
CPTCode 83835
Preferred Specimen Collection Device(s)
Reference Interval
 
Reference Intervals for 24 Hour Calculations (24-Hour Urine)
METANEPHRINE REFERENCE INTERVAL
Male AgeMale RangeFemale AgeFemale Range
0-6 yearsNot Established0-6 yearsNot Established
7-12 years45-273 ug/d7-17 years40-209 ug/d
13-17 years56-298 ug/d18 years and older36-229 ug/d
18 years and older55-320 ug/d  
NORMETANEPHRINE REFERNCE INTERVALS
Male AgeMale RangeFemale AgeFemale Range
0-6 yearsNot Established0-6 yearsNot Established
7-12 years58-670 ug/d7-12 years48-474 ug/d
13-17 years82-553 ug/d13-17 years65-406 ug/d
18-29 years81-667 ug/d18 years and older95-650 ug/d
30 years and older114-865 ug/d  
 
Creatinine, Urine - per 24 h
AgeMaleFemale
3-8 years140-700 mg/d140-700 mg/d
9-12 years300-1300 mg/d300-1300 mg/d
13-17 years500-2300 mg/d400-1600 mg/d
18-50 years1000-2500 mg/d700-1600 mg/d
51-80 years800-2100 mg/d500-1400 mg/d
81 years and older600-2000 mg/d400-1300 mg/d
 
Reference Intervals for Ratio-to-Creatinine (CRT) Calculations (Random Urine)
AgeMetanephrineNormetanephrine
0-3 months0-700 ug/g crt0-3400 ug/g crt
4-6 months0-650 ug/g crt0-2200 ug/g crt
7-11 months0-650 ug/g crt0-1100 ug/g crt
1 year0-530 ug/g crt0-1300 ug/g crt
2-5 years0-500 ug/g crt0-610 ug/g crt
6-17 years0-320 ug/g crt0-450 ug/g crt
18 years and older0-300 ug/g crt0-400 ug/g crt
No Appointment Necessary
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12 Patient Service Centers in Central New York.

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