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Discontinuation of the Clinitest for Reducing Substances in Urine and Stool - Technical Bulletin

Monday, April 6, 2020

Effective May 1st, 2020, Laboratory Alliance of Central New York will no longer be able to offer the Clinitest for reducing substances in urine as a reflex test for children less than one year of age or for urine or stool samples in adult patients.

This move is necessitated because the reagent manufacturer discontinued production of the reagent in 2015, and our current supply will expire soon. Testing urine for reducing substances was utilized for decades as a means of testing for galactosemia. This method suffered from poor specificity and has long been supplanted by mandatory newborn screenings in all 50 states which screen for more than 30 inborn errors of metabolism, including galactosemia (GALT deficiency).

Should there be a need to order the reducing substance test on stool, it can still be ordered and performed by our reference laboratory, ARUP Laboratories. Testing by ARUP is performed daily on stool by semi-quantitative colorimetry, and is reported in 1-2 days. There is no alternative testing for urine for adult patients. Please refer to the chart below for comparison of our current (discontinued) method and the alternative method available from ARUP.

  

 

Reducing Substance, Stool (Current)

Reducing Substances, Fecal (ARUP, New)

Order Code:

RSS

 

ARUP code 20373, after 5/18/20 code 3002514

 

Order Availability:

Orderable via client interfaces

Manual miscellaneous request

Method:

Copper Sulfate

Reduction

Semi-quantitative Colorimetry

Specimen Requirement:

Entire collection of stool in urine specimen cup

5 g stool in unpreserved transport vial

(ARUP # 40910)

Stability:

Refrigerated: 24 hours

Ambient: unacceptable; Refrigerated: 36 hours; Frozen: 1 week

Unacceptable:

NA

Diaper, stool w/ barium, media/preservatives

Billing Code:

4010085

None, manual billing

CPT4 Code:

84376

84376

Reference Interval:

Negative

Negative

 

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