Clozapine QCLOZ

Method(s) Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Synonym Clozapine and Norclozapine, Clozaril
Specimen Required
Collect

One 3 mL plain red (no gel) top tube.

Also acceptable

Plasma collected in: lavender (EDTA), green (sodium heparin), green (lithium heparin) top tube.

Transport

2 mL serum refrigerated (Min: 1 mL).

Stability

Ambient: 24 hours

Refrigerated: 5 days

Frozen: 30 days

Unacceptable Conditions
  • Gross hemolysis
  • Gel barrier/Serum separator tube (SST)
Schedule Mon-Fri
CPTCode 80159
Notes Performing Laboratory-Quest Diagnostics-Chantilly VA
Preferred Specimen Collection Device(s)
Reference Interval

Norclozapine: 25-400 mcg/L
Clozapine: The therapeutic response begins to appear at 100 mcg/L
Refractory schizophrenia appears to require a therapeutic concentration of at least 350 mcg/L (trough, at steady state).
Toxic range: Greater than 900 mcg/L

 

 

No Appointment Necessary
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12 Patient Service Centers in Central New York.

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