5-Hydroxyindoleacetic Acid (HIAA), Urine HIAA

Method(s) Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Specimen Required
Collect 24-hour or random urine collection. Refrigerate during collection.
Transport

4 mL aliquot from a well-mixed 24-hour or random collection at 2-8°C. (Min: 1 mL)

Remarks Patients should abstain, if possible, from medications, over-the-counter drugs, and herbal remedies for at least 72 hours prior to the test. 24-hour collections are generally recommended, but random collections may be used. Refrigeration is the most important aspect of specimen preservation. Record total volume and collection time interval on transport tube and test request form.
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 2 months

Schedule Daily
Billing Code 5010095
CPTCode 83497
Notes Foods rich in serotonin (avocados, bananas, eggplant, pineapple, plums, tomatoes, and walnuts) and medications which may affect metabolism of serotonin must be avoided at least 72 hours before and during collection of urine for HIAA.
Preferred Specimen Collection Device(s)
Reference Interval
 
ComponentsReference Interval 
5-HIAA, Urine0.0-15.0 mg/d 
The HIAA-to-creatinine ratio will be reported whenever the urine collection is random or other than 24 hours, or the urine volume is less than 400 mL/24 hours.0-14 mg/g CRT 
Creatinine (24-hour)Male
Female
 3-8 years: 140-700 mg/d3-8 years: 140-700 mg/d
 9-12 years: 300-1300 mg/d9-12 years: 300-1300 mg/d
 13-17 years: 500-2300 mg/d13-17 years: 400-1600 mg/d
 18-50 years: 1000-2500 mg/d18-50 years: 700-1600 mg/d
 51-80 years: 800-2100 mg/d51-80 years: 500-1400 mg/d
 81 years and older: 600-2000 mg/d81 years and older: 400-1300 mg/d
No Appointment Necessary
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12 Patient Service Centers in Central New York.

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