Tissue Transglutaminase Antibody, IgA with Reflex to Endomysial Antibody, IgA Titer EDAB

Method(s) Multiplex Bead Immunoassay/Indirect Fluorescent Antibody
Specimen Required
Collect One 5 mL gold (SST) top tube.
Transport

1 mL serum at 2-8°C.

Stability After separation from cells: Ambient: 8 hours; Refrigerated: 7 days; Frozen: 1 year (avoid freeze/thaw cycles)
Unacceptable Conditions

Plasma. Contaminated, heat-inactivated or severely hemolyzed samples.

Schedule Mon-Fri
Billing Code 2010221
CPTCode 83516 tTG IgA; if reflexed, add 86256 EMA titer
Notes IgA class endomysial antibodies are seen in gluten-sensitive enteropathies. Approximately 70% of patients with dermatitis herpetiformis and almost 100% of patients with active celiac disease will demonstrate IgA antibodies. These antibodies generally decrease or become negative in patients on gluten-free diets and will usually reappear upon gluten challenge. All positives are titered to endpoint. If tTG IgA is 15 U/mL or greater, then EMA titer will be added.
Preferred Specimen Collection Device(s)
Reference Interval
 
ComponentReference Interval
Tissue Transglutaminase Antibody, IgANegative: less than 15 U/mL
Endomysial Antibody, IgA TiterLess than 1:10
No Appointment Necessary
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11 Patient Service Centers in Central New York.

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